My summary: Methylation and transsulferation work together so excess dietary sulfur can interfere with methylation. the food reintroduction process: Sulfur: For 1-4 days eat multiple servings of high sulfur foods over the course of each day. Even by age 13, I had developed severe bladder problems when I was on the basketball team. I was getting rashes, large welts and ringing ears along with brain fog from almost all of the antibiotics, including sulfa drugs (this last is a clue towards one having high thiol sulfur sensitivity). Dr. Laurence Wilson, MD, from Arizona comes to mind. If its not that, I can tell you Ive been mostly able to avoid these episodes by quitting all alcohol and wheat and avoiding preservatives/prepared foods. When eliminating thiols from the diet it is important to know that some supplements and medications also contain them or can increase levels of thiol in the blood. Bjrklund, Geir et al. I dont have even the slightest doubt that I have mercury and other heavy metal toxicity. This means the enzyme works too fast. Eventually, through extensive trial and error, I figured out I am very sensitive to the wheat family and most milk products, although I kept eating yogurt for years. Follow Guts Grit and Growth on Facebook, Pinterest and Instagram for all of the latest content and make sure to subscribe to the email list. But after having toxic mold exposure a bunch of times from work these past couple years its gotten exceptionally bad. I take active sublingual B12 drops as I find they work far better for me than tablet or capsule forms, & I also take a good B-50 complex because B vitamins are synergistic & all support each other in various ways, so taking one in isolation may potentially deplete others. 2. But now after the mold exposure with my last allergy test Ive had to cut out all Lectin foods, all the night shades, and all high sulfur foods. A Review on Coordination Properties of Thiol-Containing Chelating Agents Towards Mercury, Cadmium, and Lead.Molecules (Basel, Switzerland)vol. Dr. Ben Lynch offers this key advice in his book: it is important for most of us to eat a bit of carbohydrate, protein and fat with each meal in order to support and not stress things out like serotonin and dopamineespecially important for someone like me and my friend who have COMT snyps too. Names I recall are Benjamin Lynch (Seattle area), Josh Axe and Dr. Jockers, all of whom you can find online. References1. Hops such as Nelson Sauvin, Amarillo, Mandarina Bavaria, Mosaic, Citra, Cascade, Calypso and Tomahawk are high in these thiol compounds. Heat on low for 6 hours. I started noticing that my urine smelled bizarre/off after ingesting eggs (and then started noticing with broccoli, onions, garlic). Definitely will try butternut squash soon. It begins ten days after the last ingestion of substances with a high thiol content. In case you want to learn more about CBS and low thiol foods plus COMT, here are some good links below that you can check out. Im talking about those compounds that are thiols or that metabolically convert to them, not to the total amount of elemental sulfur in the food. Thiols, molecules that contain a sulfhydyl (SH) side chain group, act as antioxidants, stabilizing free radicals by accepting their unpaired electron. Broccoli Cauliflower Dark Leafy Greens Cabbage Onions Leeks Garlic Dairy - milk, cheese, cream, sour cream Eggs, especially egg yolk Red + white meats, fish Legumes Coffee Chocolate Peanuts Shallots Soy milk, tofu, temphe Spinach Quinoa Chlorella MSM Tumeric (good at raising thiol levels) Add Molybdenum. my symptoms: fowl egg smell constantly, headaches, bloating, high blood pressure, rash( unexplained) fowl smelling gas (like rotten eggs), Gluten makes my rash worse, dairy makes my mouth taste awful. The whole idea is to keep charcoal continually in your gut (12 hrs is all things stay in there) so that it filters out the mold and keeps the mold levels down in your fluids so your body can heal. If you are sulfur-sensitive, you may only tolerate small amounts of ALA, so start low just in case. Thiols play significant roles in the aroma qualities of a range of foods and beverages, including wine, with extremely low odour detection thresholds (nanogram per litre range). For example, meat and nuts may contain high amounts of sulfur, but not thiols, but may contain sulfites if added. Now Im trying to eliminate the biggest offenders (high sulfur/sulfite foods). Youll see the product of my work in the photo at the right which was my breakfast this morning. Also, do not take ALA during your sulfur exclusion trial. The study of Methylation, genetic snps and epi-genetics has finally started to progress to where it can help many people struggling with underlying health problems. I keep getting yeast infection in my mouth, I think they call Candida. cheers ,ahmo Many people told me my symptoms were just detox and to push through. NOTE: While some physicians think the CBS mutation is one of the most important mutations to address, there is very little medical research to support these claims and some doctors in the field disagree. And yes we just had another a big discovery for my friend. Beagarth, you see to have heard of Andrew Cutler, have you tried the chelation protocol? Do you herx on this protocol? There is also an introduction which discusses what mercury toxicity is all about. If you are over-methylating (which I am), you may have this also. That in combination with a couple of my stressed COMT genes (and those of my friend) makes a very difficult stew, so to speak. The CBS upregulation has been clinically observed to result in sulfur intolerance in some patients. Spinach, lentils, beans, chickpeas, asparagus, broccoli, eggs, garlic, onions, kale, peas and loads of other healthy thiol stuff too. It all started about 3 months after going vegan and plant basedmy B-6 levels are twice the normal range according to blood workIve tried the fodmap, low oxalate and low salicylate diets for the past few weeks but havent found major reliefso I suspect it may be a sulfur issue as my food sensitivity test showed sensitivity to eggs, mushrooms, multiple grains, garlic and onions and soy. I have quite a few gene mutations of which MTHFR ( methylation) and CBS ( transulfuration) are effected. I have everything you talked about. I did experience all of those things at one time or another wish I could be of more help. Thanks so much for this. Instead it shows itself in other symptoms like the insomnia and aching joints. 31 0 obj
<>/Filter/FlateDecode/ID[]/Index[11 35]/Info 10 0 R/Length 101/Prev 104063/Root 12 0 R/Size 46/Type/XRef/W[1 3 1]>>stream
Dr. Lonsdale discovered that IV B12 lowered high B6, suggesting that B12 & B6 have a working partnership and the body may retain B6 in anticipation of the B12 being converted to its active forms so the interaction can occur. be well. The only way I could get relief was to dramatically lower my sulfur intake including protein. The disulfide linkages contribute to the tertiary and quaternary structures of proteins. This is despite evidence tat unofficial testing revealed high levels of glyphosate in many household foods. Hugs ~ Cynthia. What is an example of a thiol supplement? Is there a low-sulfur foods list thats accurate? I was getting weaker and weaker, not to speak of the embarrassment of having weird hours due to my inability to sleep on any kind of regular schedule. hb```"V
s00o This has nothing to do with plasma sulfate (SO4) status or liver sulfation status. Could easily be the wheat, no? Decrease your sulfur levels by choosing foods with lower amounts of sulfur: Most fresh fruits and select vegetables. Help anyone? And when I cook fresh eggs they smell rotten to me. I lived fairly normally if a little subdued by lack of endurance at times. It turns out he needs to avoid high histamine foods, the very opposite of what we thought! Andy Cutler also says: If you have elevated cysteine and you want to convert some to glutathione, take a 2:1 weight ratio of glutamine and glycine (e. g. 2 500 mg caps of glutamine with 1 500 mg cap of glycine) and your body will do the rest.. Instead I eventually discovered I am very sensitive to high histamine foods, which includes a lot of fruit, and to any fruit that is over-ripe. A high-protein, low-calorie diet typically yields 5 grams a day, whereas a dieter might consume 3.5 grams a day. If you feel worse soon after introducing sulphur foods, you do not need to complete a week of sulphur challenge as it indicates you will feel better eliminating sulphur foods. A lot of what you and your friend have been going through sure sounds a lot like its heavily related to mold toxicity. No doubt this mercury toxicity underlay my developing kidney disease when I was 23. But, a year ago this month, I crashed becoming wheelchair bound and bedridden now for 1 year. And he works a lot with the CBS mutation and works a lot with a low sulfur diet. bromelain and papain (use enzymes derived from animals). I'm trying the low-sulfur and methylation diet at the same time. It has also been observed that BH4 can also become depleted with a CBS upregulation. He is being similarly helped by this new diet even though his epi-genetics and symptoms have presented themselves differently than mine. However I was still eating kale and occasionally bok choi. Vegetables should be limited to things like corn, cilantro, parsley, Jerusalem artichoke, carrots, potatoes, sweet potatoes, and yams. veggies, eggs, eat a small palm-sized amount of meat 2x/day. * how to get healthy. Chlorophyll can be helpful for mopping up extra ammonia in the system and I take that every few days. I soon discovered she was right. Many misleading sulfur food lists on the web are simply indicating the total amount of elemental sulfur, rather than talking about foods that contain thiols, or that metabolically convert into them. Thiols are formed during coffee roasting and are described as the key odorants responsible for the typical coffee and roasty odour notes, greatly influencing the sensory characteristics of coffee. This can mean the difference between wanting to wake up in the morning, to wanting not to (and all that implies). Add to batter. Please check it out and join it! ( 1 ) But many of these same fish also can contain the highest heavy metal concentrations, specifically because heavy metals have an affinity for being sequestered in fat. boosting mental performance and memory. Food that is high in sulfur include: Eggs Garlic Kale Onions Nuts Cruciferous Vegetables Meat The highlighted foods are most common. Anyone have this kind of thing? Many supplements contain sulfur so please do your research before you purchase one. Pam! They supply each other with substrates and work together like gears, so if one cycle isnt moving in a progressive direction, the other two may not be either. It is possible for cysteine status to change as chelation progresses. Thiols in food and supplements are unique in that they can grab hold of mercury in your body and move it around causing symptoms typical of heavy metal poisoning. My symptoms were: hoarseness (like chronic laryngitis), constant belching something Id never had before, low energy, low pulse (bradycardia), foggy thinking, dry eyes but watery in appearance, and difficulty in taking a deep breath. Please tell your friend about it too this is so far the only safe method out of this mess. [I] made a massive diet change yesterday, replacing 80 to 90% of my diet a change that frightened me as much or more than going vegan. Although Im following as many doctors as I can who are interested in sulfur intolerance, I am not a doctor and I am speaking solely out of personal experience. For this reasoning, I have chosen to rank foods in the chart according to their sulfite and thiol content. 3. My gut feeling was telling me that I should eat the donut. So now I am drinking more of my bitter tea before and after meals knowing it helps with digestion and dissolving oxalates. I have had allergy tests done, altra sounds, upper and lower GI, blood work and urine tests. You can request a genetic test from your PCP. Whilst it should ideally be produced by gut microbes, many of us have decimated gut biomes from antibiotic use, exposure to other biome-wrecking drugs & chemicals such as Glyphosate, etc, so have no way of producing or metabolising it other than to get it from animal foods or take supplements. High in sulfur. In some people this genetic polymorphism speeds up production of sulfur, in others this slows it down. Today I am really out of it. The plasma cysteine test is not available anymore. }Vssa8
`igL8V^SFN F#G%jmEs}C}n[B5-
xuiOGcM##aTy6F8ClRDMmZ]<4c!-J 1Ys`#l`^t Are you struggling to figure out which foods are safe to eat on a low thiol diet? I would like to hear from someone who has done this for a year or so and hasnt had symptoms of protein deficiency ( hair, skin, nail issues) Thank you for this welcome (and rare!) Ive been gluten free for almost 20 years, that helped my acne a lot. Hi. Now on low thiol foods plus of course continuing to eat fairly low histamine foods with no gluten or milk products etc., both my friend and I are starting to sleep better at night plus we are starting to feel more energetic and clear. * hair test Improved energy, digestive function, a clearer brain, improved food tolerance and hormone regulation to name a few. Excess sulfur generates excess sulfur breakdown products like hydrogen sulfide, sulfite and other toxic molecules. This comes and goes. NAC is an example of a thiol supplement. Plus more recently the high thiol foods and supplements have been creating problems for me with such things as sleep, skin, collagen issues and nerve degeneration due to my continued toxicity.